Zishen decoction combined with standard treatment of western medicine for stage IV diabetic nephropathy with Qi and Yin deficiency

Abstract

Objective To evaluate the therapeutic effect of Zishen decoction combined with standard treatment of western medicine for for stage IV diabetic nephropathy with Qi and Yin deficiency. Methods A total of 112 patients with stage IV diabetic nephropathy and Qi and Yin deficiency were randomized to thestandard treatment and the combined treatment groups, 56 in each. The standard treatment group received conventional treatment, including blood glucose controlling, antihypertensive, blood lipid regulating and diet controlling. The combined treatment group received Zishen decoction on the basis of conventional treatment. All the patients were treated for 3 months. The blood urea nitrogen (BUN), serum creatinine (SCr), total cholesterol (TG), triacylglycerol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and glycated hemoglobin (HbA1c) were measured by an automatic chemistry analyzer. The urinary albumin excretion rate (UAER) was measured by the enzyme-linked immunosorbent assay. Results Compared with the standard treatment group, the SCr (53.51±18.12 mol/L vs. 62.66±21.14 mol/L; t=2.459, P<0.05), UAER(100.73±84.24 g/min vs. 156.24±96.38 g/min; t=3.245, P<0.05), TG(1.73±0.22 mmol/L vs. 2.06±0.21 mmol/L; t=8.112, P<0.01), TC(4.56±0.62 mmol/L vs. 5.10±0.31 mmol/L; t=5.830,P<0.01), LDL-C (2.42±1.05 mmol/L vs. 3.31±0.81 mmol/L; t=5.022, P<0.01) in the combined treatment group decreased significantly, and the HDL-C (1.67±0.33 mmol/L vs. 1.36±0.41 mmol/L; t=4.460, P<0.01) increased significantly. Conclusion Zishen decoction on the basis of conventional treatment can improve the SCr and UAER, and regulate the blood lipid in the patients with stage IV diabetic nephropathy and Qi-Yin deficiency. Key words: Diabetic nephropathies; Qi-Yin deficiency; Integrated Chinese and western medicine therapy; Treatment effect; Zishendecoction