Zingiber officinale ethanolic extract improved organs function in lipopolysaccharides-induced organ toxicity by modulating inflammation and oxidative stress in male rats

Abstract

ABSTRACT Bacterial lipopolysaccharide (LPS) is the typical inflammatory and oxidative stress agent; ginger (Zingiber officinale) has long been utilized to treat inflammatory conditions. This study aimed to evaluate the possible therapeutic role of ginger extract (GE) against LPS-induced hepato-renal and testicular injury. Male rats received GE (150 mg/kg, orally, for 28 days) after the inflammation shock was provoked by a single intraperitoneal injection of LPS (5 mg/kg). Rats treated with LPS exhibited marked inflammation and oxidative stress, in addition to liver and kidney injury and disruption of male sex hormones. The treatment of LPS-injected rats with GE resulted in a remarkable return to normalcy of the oxidative stress in the rats, as evidenced by a notable decrease MDA and an amelioration of SOD and CAT activities. On the other hand, the rats administered LPS and GE had considerably decreased serum levels of TNF-α and IL-6, improvement in serum albumin, total bilirubin and ALT and AST activity, urea, creatinine, and uric acid as well as FSH and testosterone levels. This indicating improved liver, kidney and testicular functions. In conclusion, GE attenuates the inflammatory damage and oxidative stress caused by LPS, which helps to restore organ function.