Abstract
AbstractWith the catalysis of Zn(OTf)2, Mannich‐type reactions of various aromatic hydrazones 1 with difluoroenoxysilane 2 proceeded smoothly to produce 2,2‐difluoro‐3‐oxo‐benzohydrazides in 27% –78% yields in THF or DCM under mild conditions. An unexpected monofluorination of hydrazone 1m with difluoroenoxysilane 2 was also disclosed in this paper. The first example of the asymmetric Mannich‐type reaction of hydrazone 1a with difluoroenoxysilane 2 using chiral phosphine‐oxazoline ligand has been reported, giving the adduct 3a in good yields and moderate enantioselectivities under mild conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
