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A chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi resulted in the discovery of four new (1—4) and one known (5) meroterpenoids. Compound 3 significantly blocked the mTOR signaling pathway, resulting in the arrest of cell cycle at G0‐G1 phase and triggering mitochondrial apoptosis in Hela cells. While macrophorin A effectively triggered cell death in MDA‐MB‐231 cancer cells by activating apoptosis pathways involving death receptors, mitochondria, mTOR, and TNF. More details are discussed in the article by Yang et al. on pages 3283—3292. image