Zinc Nutritional Status in Patients with Cystic Fibrosis.

Marlene Fabiola Escobedo Monge,Carmen Alonso Vicente,José Manuel Marugán De Miguelsanz,María Paz Redondo Del Río,Enrique Barrado

doi:10.3390/nu11010150

Marlene Fabiola Escobedo Monge, Carmen Alonso Vicente + Show 3 more

Open Access

https://doi.org/10.3390/nu11010150

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Journal: Nutrients	Publication Date: Jan 11, 2019
Citations: 23	License type: CC BY 4.0

Affiliation: University of Valladolid

Abstract

Background: Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. Objective: The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients. Methods: A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted. Hypozincemia was determined by SZC while using atomic absorption spectrophotometry and dietary zinc deficiency by prospective 72-h dietary surveys. Results: Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Three of 17 patients with CF (17.6%) had hypozincemia and four (23.5%) had a dietary zinc deficiency. No patient with dietary zinc deficiency had hypozincemia. A positive and significant association was observed between SZC and Z-score of BMI-for-age (p = 0.048) and weight-for-height (p = 0.012) and between dietary zinc intake and energy intake (EI, p = 0.036) and Z-score of weight-for-high (p = 0.029). Conclusion: SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. No patient with hypozincemia had dietary zinc deficiency. This situation should alert us to a marginal zinc deficiency and it may explain why there were no overlapping cases between the two groups. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered.

Highlights

Cystic fibrosis is a chronic autosomal recessive disorder that affects the lungs and the digestive system of approximately 70,000 people worldwide and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [1]
The genotype of cystic fibrosis subjects was elaborated by Biological and Molecular Genetics of the School of Medicine at Valladolid University (Table 2)
Dietary zinc intake was associated with nutritional status expressed as energy intake and weight‐for‐height

Summary

Introduction

Cystic fibrosis is a chronic autosomal recessive disorder that affects the lungs and the digestive system of approximately 70,000 people worldwide and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [1]. 2000 different disease-causing mutations have been identified, but the most common mutation (approximately 70% of patients) is a three-base-pair deletion (CTT) in exon 10. This mutation causes an in-frame deletion of a phenylalanine residue (DF508) and it results in the lack of a functional cAMP-gated chloride channel on the apical surface of secretory epithelial cells [2]. Results: Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Conclusion: SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered

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