Abstract

The rapid development of the nanomaterials’ application’s fields in biomedicine is associated with the expanded possibilities of combining their properties in composite materials. The use of nanocomposites allows application in various types of therapy or theranostics. In this work, we propose a new approach for the fabrication of a gold/ferrite nanocomposite, which consists of gold particles up to 10 nm in diameter surrounded by small nanoparticles of cobalt ferrite (~5 nm) doped with zinc. The gold core is coated with arginine, while the ferrite particles have dihydrocaffeic acid shell. The fabricated nanocomposite possesses optical and magnetic properties due to the excitation of localized plasmon resonance in gold particles and the superparamagnetic state of ferrite particles. The results of studying the structural, magnetic, and optical properties, as well as the cytotoxicity of the obtained nanocomposite, allow us to conclude that it can be used in combined photo- and magnetic hyperthermic therapy.

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