Abstract
The high-performance electrochemical detection relies on sensing material with highly active structure, which requires the development of advanced synthesis technique and the study of its structure-activity mechanism. Herein, the few-layer Ti3C2Tx nanosheets densely coated zeolitic imidazole framework-8 nanoparticles (Ti3C2Tx@ZIF-8) have been successfully prepared as a unique precursor, which combines the structural advantages of two-dimensional Ti3C2Tx and porous ZIF-8 nanoparticles, leading to the vast interior spaces for loading electrocatalytic nanomaterials. For this purpose, Ti3C2Tx@Au nanoparticles-ZnO nanoparticles@N-doped carbon (Ti3C2Tx@AuNPs-ZnO@NC) has been obtained for the simultaneous electrochemical detection of pharmaceutical molecules including dopamine (DA), acetaminophen (AC), and xanthine (XA). The materials characterization and sensing analysis results of Ti3C2Tx@AuNPs-ZnO@NC reveal the structure-activity relationship of Ti3C2Tx, AuNPs and NC resulting in the high-performance behaviors, which can be summed up as stable electrochemical active sites and efficient electron transport channels. First, the abundant anchor points are offered by NC for immobilizing AuNPs, which ensure the electrochemical activity of such material. Second, the close combination of few-layer Ti3C2Tx nanosheets and NC provides an ideal channel for electron transmission along with the electrochemical reaction process. The potential application of Ti3C2Tx@AuNPs-ZnO@NC is displayed to develop the electrochemical medical sensor. The detection limits are 41 nM towards DA, 59 nM towards AC, and 67 nM towards XA. The linear ranges are 3–200 μM for DA, 15–500 μM for AC, and 8–350 μM for XA.
Published Version
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