Zero-/two-dimensional coordination complexes based on the substituted imidazo[1,2-a]pyridine ligands: structural diversity and antitumor activity on human myocardial aneurysm cells

Abstract

In the current study, two similar substituted imidazo[1,2-α]pyridine ligands with different coordination groups were facilely synthesized, and were further used for construction of two novel Cu(II)-based coordination complexes with the chemical formulae of Cu(L1)2(H2O)4 (1, HL1 = (E)−4-(3-(2-chloroimidazo[1,2-a]pyridin-3-yl)acryloyl)benzoic acid) and [Cu(L2)2]n (2, HL2 = (E)−4-(2-chloroimidazo[1,2-α]pyridin-3-yl)−2-oxobut-3-enoic acid) via a one pot solvothermal reaction. In addition, their inhibitory effect on human myocardial aneurysm cells were evaluated. Firstly, to explore the inhibitory effect of complexes on cancer cell viability and proliferation, the Cell Counting Kit-8 (CCK-8) assay was performed. Next, to evaluate the influence of the compounds on the cell migration and invasion ability, the transwell assay was conducted. In addition to this, for the cancer cell apoptosis evaluation after compounds treatment, the flow cytometry was carried out in this research.