Abstract

Exposure to both UVA and UVB radiation from the sun stands as the primary cause of skin cancers, contributing to the escalating yearly count of diagnosed cases. Sunscreen products, (i.e. organic and inorganic UV filters) have become ubiquitous in personal-care products, packaging, plastics, dyes, and many other sectors. Ideal UV filters should be photostable and dissipate the absorbed energy efficiently. However, most organic UV filters are photolabile upon protracted UV exposure, leading to the formation of photoproducts of unknown toxicity for human health and environment. The chemical environment surrounding UV filters may strongly affect their behaviour: the interaction with other components of sunscreen formulations may enhance their degradation. Particularly, the interaction between photochemically incompatible ingredients must be avoided. Therefore, much effort has been invested in developing more effective and safe sunscreens.Our team recently focused on the preparation and characterization of hybrid UVfs obtained by the encapsulation of organic UV filters into various zeolites differing for topology. The zeolite most efficient for the encapsulation of organic UV filters, in term of stability and efficiency in radiation filtration, resulted to be LTL zeolite. Here, hybrid materials realized after the encapsulation of octinoxate (OMC) and avobenzone (AVO) in LTL zeolite were tested in terms of skin permeation profiles, cytotoxicity and photostability once the materials are dispersed in cream formulations, so to mimicking the real condition of use.The results show that the hybrids were successfully incorporated into oil-in-water emulsions and the skin permeation tests displayed a very low UV filter permeation through pig skin and no UV filter accumulation in dermis layer.The photostability of the hybrid-based emulsions were compared with that of emulsions containing a mixture of bare OMC and AVO, highlighting a reduced decrease in UV screening efficiency upon irradiation for the samples containing the hybrid materials with respect to the free filters. This evidence confirms that the encapsulation in the zeolite frameworks prevents some of the photodegradation reactions. The result of this paper highlights that zeolite encapsulation is increasingly establishing as a viable way to stabilize UV filters and other photoactive molecules.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call