Zebrafish as a fascinating animal model: a robust platform for in vivo screening for biomedical researches

Abstract

Due to its striking similarities in anatomy, physiology and genetics with humans, the zebrafish (Danio rerio), a little tropical freshwater fish, has seen massive adoption as a model. Thus, zebrafish are a great model to study human disease mechanisms in the areas of toxicology, genetics and behaviour. Due to its shared vascular system, musculature, renal system and ocular structures with humans, the zebrafish is classified as a vertebrate. Because of the striking similarities between the human genome and that of zebrafish including the arrangement of genes and the pathways that regulate signal transduction, zebrafish might one day be used to simulate human illnesses. There are many screening models present for the determination of preclinical screening activity of the drug molecule. The main objective of this study is to find at which model is best having low cost. A literature search was conducted on the databases namely Science direct and PubMed with the help of different keywords such as "Zebrafish", "In vitro models" and "In vivo models". The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article: There were different research and review papers based on the Zebrafish models for the determination of different activity of new drug molecules. We found some useful models for the different activity of drugs and suggested that, if we used different methods together, then we may obtain the most relevant result in our research area.