Zastosowanie pregabaliny u chorej z bólem neuropatycznym w przebiegu neuropatii obwodowej indukowanej chemioterapią – opis przypadku

Abstract

Chemotherapy-induced neuropathy (CIPN) is a frequent iatrogenic complication and a consequence of causal treatment of neoplastic disease. The risk of developing CIPN depends on the type of chemotherapy, the total dose, but also on the patients’ factors. There is currently no proven method that can prevent the occurrence of CIPN. Neuropathic pain may occur in 40% of patients with CIPN, decreases patients’ quality of life and can be treated symptomatically only, both with pharmacotherapy and non-pharmacological methods. Antiepileptics, antidepressants, opioid analgesics and topical drugs are recommended. These drugs have proven their effectiveness in the population of patients with neuropathic pain unrelated to cancer treatment, but there are still no high-quality studies assessing their effectiveness in patients with CIPN. Studies in small groups of patients available in the literature confirm the effectiveness of antiepileptic and antidepressant drugs in this group of patients, what is observed in clinical practice as well. The article presents a case of a patient with severe neuropathic pain in the course of CIPN who was successfully treated with pregabalin in combination with duloxetine.