Yüksek Dereceli Glial Tümörlerin Radyoterapisinde VMAT Tekniği İle IMRT Tekniğinin Karşılaştırılması

Abstract

The aim of radiotherapy is to protect critical organs sensitive to radiation and surrounding healthy tissues as much as possible, while giving the most appropriate dose on the specified target volume. The aim of this study is to provide the best plans of 10 brain tumor patients, whose computed tomography (CT) image was taken, using the best plans created using the VMAT technique in the Eclipse treatment planning system and the best plans created using the seven-field IMRT technique to compare doses in terms of target volume, duration of treatment and monitor unit (MU) values. The study is a retrospective study and patients were not treated with the plans and techniques used in the studies. Plans have been made so that 100% of the dose defined for the target volume will take at least 95% of the target volume. Using the Radiation Therapy Oncology Group (RTOG) protocol, the results obtained with the minitab program were statistically evaluated using the t-test for the matched data. PTV coverage, conformity and homogeneity index were equivalent for VMAT and IMRT plans. VMAT plans compared to IMRT, PTV max. 64,835±0,504 (p=0,039), Brain max. 64,378±0,565 (p=0,025), and Eye L. max. 20,39± 12,17 (p=0,046) The difference between the mean doses is statistically significant. Brain mean 26,74±3,42 (p=0,096), Brainstem max. 32,44±18,70 (p=0,178), Eye R. max. 32,90± 16,84 (p=0,076), Optic Nerve L.max. 23,17± 15,45 (p=0,851), Optic Nerve R. max. 22,63± 17,98 (p=0,688), Optic Chiasma max. 25,25± 20,24 (p=0,531) were found lower in VMAT plans but it was not statistically significant. It may be preferred in plans made with the VMAT technique due to less monitor units (MU) and shorter treatment time.