Y2O3/HAp, a sustainable catalyst for novel synthesis of furo[3,4-b]chromenes derivatives via green strategy

Abstract

A green, facile and multicomponent reaction for the preparation of furo[3,4-b]chromenes using a recoverable and reusable yttria doped hydroxyapatite (Y2O3/HAp) solid material as the heterogeneous catalyst is described. The reaction progresses with mixing the aldehyde, 4-hydroxyfuran-2(5H)-one, 5,5-dimethylcyclohexane-1,3-dione and Y2O3/HAp at R.T. in ethanol solvent media to obtain the desired target molecules in excellent yields (91–98%). The proposed approach shows noteworthy benefits such as ecofriendly, non-toxic solvents, easy handling, short reaction time (10 min), simple workup procedure, avoiding column chromatography and reusability of the catalyst, proving vital green chemistry principles.