Abstract
IntroductionX-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy.MethodsA systematic review and meta-analysis was performed to evaluate the predictive value of XRCC3 Thr241Met polymorphism on clinical outcomes of advanced NSCLC receiving platinum-based chemotherapy. Response to chemotherapy, overall survival (OS) and progression-free survival (PFS) were analyzed.ResultsA number of 11 eligible studies were identified according to the inclusion criteria. Carriers of the variant XRCC3 241Met allele were significantly associated with good response to platinum-based chemotherapy (ThrMet/MetMet vs. ThrThr: OR = 1.509, 95% CI: 1.099–2.072, Pheterogeneity = 0.618). The XRCC3 Thr241Met polymorphism was not associated with OS (MetMet vs. ThrThr, HR = 0.939, 95% CI:0.651–1.356, Pheterogeneity = 0.112) or PFS (MetMet vs. ThrThr, HR = 0.960, 95% CI: 0.539–1.710, Pheterogeneity = 0.198). Additionally, no evidence of publication bias was observed.ConclusionsThis systematic review and meta-analysis shows that carriers of the XRCC3 241Met allele are associated with good response to platinum-based chemotherapy in advanced NSCLC, while the XRCC3 Thr241Met polymorphism is not associated with OS or PFS.
Highlights
X-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway
Molecular epidemiology studies have documented that lung cancer risk [8,9], DNA repair capacity and levels of DNA damage [10] may be modulated by single nucleotide polymorphisms (SNPs) of genes in the DNA repair pathways like, double-strand break (DSB) repair, base excision repair (BER) and nucleotide excision repair (NER)
In this systematic review and meta-analysis, we comprehensively evaluated the correlation between XRCC3 Thr241Met polymorphism and clinical outcomes of advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy
Summary
X-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. Molecular epidemiology studies have documented that lung cancer risk [8,9], DNA repair capacity and levels of DNA damage [10] may be modulated by SNPs of genes in the DNA repair pathways like, double-strand break (DSB) repair, base excision repair (BER) and nucleotide excision repair (NER). A number of studies have investigated the association of XRCC3 Thr241Met polymorphism with clinical outcomes of NSCLC receiving platinum-based chemotherapy [13,14,15,16]; the results were quite controversial and inconsistent
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