Abstract

Experiments on the feasibility of x-ray monitoring of laser interstitial thermotherapy (LITT) of breast cancer are presented. Digital images of heated tissue phantoms (including fatty porcine tissue and polyacrylamide/acrylate hydrogel), obtained from an x-ray stereotactic biopsy system, were analyzed for changes in pixel intensity. Tissue phantoms were heated either by a 980 nm diode laser or by resistive heating elements in a custom-made chamber. Analysis was conducted by evaluating the changes in average pixel intensity of regions of interest. Image constancy and stability of the x-ray system were also investigated. Slight changes (less than 5%) dependent on the temperature of the tissue phantom were observed, while changes caused by heat- induced tissue displacement and/or shrinkage were more significant (greater than 10%).

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