Abstract
A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinularia nanolobata. The structures of the new compounds were elucidated by extensive analysis of spectroscopic data.
Highlights
Chromatographic separation on the acetone extract resulted in the isolation of two new terpenoids, sinubatin A and B (1 and 2), as well as a known compound, gibberosin J (3)
Chemical shifts are expressed in δ referring to the solvent peak δH 7.27 for CHCl3 and coupling constants are expressed in Hertz (Hz). 13 C nuclear magnetic resonance (NMR) chemical shifts are expressed in δ referring to the solvent peak δC 77.0 for CDCl3
The acetone extract (30.0 g) of S. nanolobata was concentrated under reduced pressure to a brown gum, which was partitioned between EtOAc and
Summary
Soft corals coralsofofgenus genus (Alcyoniidae) reported besource a richofsource of novel. Soft havehave been been reported to be a to rich novel structures structures andterpenoids bioactive terpenoids and [1].studies. 4,5-epoxycaryophyllene possessing possessing an unusual methylfuran methylfuran moiety side chain), and gibberosin. The structures of and were determined by moiety side chain), and gibberosin J (3) (Figure 1). The structures of 1 and 2 were determined extensive spectroscopic analysis. The chemical structure of gibberosin was determined by by extensive spectroscopic analysis. The chemical structure of gibberosin J (3) was determined by comparison of ofits itsinfrared infrared(IR),. Spectroscopic data with the literature data [7]. Nuclear magnetic resonance (NMR) spectroscopic data with the literature data [7]
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