Synthesis of Novel Tetranorlabdane Derivatives with Unprecedented Carbon Skeleton

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Synthesis of novel tetranorlabdane derivatives including hybride with terpeno-(1,2)-diazine units and dimers with an unprecedented carbon skeleton, was performed based on methyl 7-oxo-13,14,15,16-tetranorlabd-8-en-12-oate intermediate. The structures of the synthesized compounds have been fully confirmed, including by X-ray diffraction, and their antifungal and antibacterial activity was tested. A possible mechanistic pathway of the cycloaddition reaction is considered.