Abstract
SummaryThe effect of theXce(x-chromosome controlling element) genotype on the randomness ofX-chromosome inactivation in the mouse was studied by monitoring the expression of theX-linked locuspgk-1. The main aim was to test whether theXcegenotype modified the preferential expression of the maternally derivedX-chromosome in the yolk sac endoderm. Quantitative electrophoresis of phosphoglycerate kinase (PGK-1) was used to studyPgk-1expression in the foetus, yolk sac mesoderm and yolk sac endoderm at 13½ dayspost coitum. TheXcea/Xcecgenotype caused non-randomX-chromosome expression in the foetus and yolk sac mesoderm. However, there was no evidence that theXcegenotype moderates the preferential expression of the maternally derivedX-chromosome in the yolk sac endoderm, as reported by Rastan & Cattanach (1983).
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