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Abstract
An adaptation of the XC cell cytopathogenicity test for detection of murine leukemia virus (MuLV) and MuLV-infected cells was used for assaying murine myeloma C-type virus. Fusion-inducing activity was present in MOPC-21 and FLOPC-1 (filter-Lucite-originated plasma cell tumor) cell culture lines, as well as in the gradient-purified C-type virus. Activity was not present in MOPC-21 and FLOPC-1 cells from in vivo tumors, which corresponded with electron microscopic evidence that the in vivo tumor cells were devoid of any C-type virus. Syncytium formation induced by cells or purified virus was not prevented by treatment with several inhibitors of macromolecular synthesis. However, extracellular fusion-inducing activity was sensitive to temperature, trypsin, ether, ultraviolet light, and RNAse.
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