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Abstract
Immunoelectron microscopy was applied to analysis of a) antigenic properties of type-C viruses and b) the appearance of differentiation antigen PC1 in primary and/or short-term transplanted mineral oil-induced myelomas of 4 mouse strains (BALB/c; 2 recombinant strains, C × BG and C × BJ; and C57BL/6). In PC+ strain BALB/c mice, primary myelomas whose cells carried PCl antigen produced many type-C viruses. These viruses were classified into 3 populations: murine myeloma-associated viruses (MuMAV) carrying a type-specific virus envelope antigen xVEA distinct from known typical murine leukemia virus (MuLV); MuLV (Gross); and other yet uncharacterized type-C viruses. In PC- strains, where normal plasma cells carried no PCl antigen, myeloma cells from some mice became PC+ and released complete type-C viruses, either xVEA+MuMAV alone or all 3 populations. However, some mice developed PC- myelomas accompanied by no viruses or only uncharacterized viruses. These results led to 2 possible conclusions: that PC1 antigen was perhaps induced by xVEA+ MuMAV; and that xVEA+MuMAV and/or the uncharacterized type-C viruses may have had an important role in the development of some myelomas. The finding of PC1 antigen on macrophages added new information on the tissue distribution of this antigen.
Published Version
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