Abstract
In a previous publication (1) the isolation of a green pigment from the urine of pyridoxine-deficient rats was described. The green pigment was shown to be the product of a reaction between ferric ammonium sulfate or other ferric salts and a compound whose nature was unknown. This compound has now been isolated in crystalline form. It is a yellow pigment and has been identified as xanthurenic acid.
Highlights
Pyridoxine-deficient rats were put in metabolism cages” and the presence of xanthurenic acid in their urine was established by the production of the
Perhaps the excess protein destroys pyridoxinc in the rat in some unknown way. Such a phenomenon would explain the early appearance of xanthurenic acid in the urine of rats and rabbits (6) fed high protein diets
Kotake and Iwao (13) isolated kynurenine as an intermediary product in tryptophane metabolism and reported that kynurenine is excreted as a potassium salt, whereas kynurenic acid is found as a sodium salt
Summary
In a previous publication (1) the isolation of a green pigment from the urine of pyridoxine-deficient rats was described. The green pigment was shown to be the product of a reaction between ferric ammonium sulfate or other ferric salts and a compound whose nature was unknown This compound has been isolated in crystalline form. The column was washed with saturated sodium chloride solution, which carried through most of the urinary constituents before the yellow pigment came through. The sodium chloride-saturated solution containing the yellow pigment was concentrated to about one-tenth of its volume and the precipitated sodium chloride removed by filtration. At this point, two different procedures were employed.
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