Abstract
It is a challenge in clinical practice to estimate Time Enhancement Curves (TEC) of a Region Of Interest ( ROI ) in real time from intraoperative X-ray projection movies. In the past, TEC was estimated by obtaining the Standard Linear Attenuation Coefficient Distribution (SLACD) from a preoperative contrast-enhanced CT and combining it with an intraoperative X-ray projection movie. However, in actual clinical practice, the SLACD is often uncertain due to the unavailability of preoperative contrast-enhanced CT images and the patient's respiratory motion. We developed a method for estimating TECs at a newly defined Node Of Interest (NOIs) by applying Singular Value Decomposition ( SVD ) and prior information to intraoperative X-ray projection movies only. To validate the effectiveness of this method, twin numerical experiments were conducted using a simulated blood vessel model, and the estimation results were compared. The estimation results show that the method is able to accurately estimate the rise time of TECs and the frame of maximum concentration.
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