Abstract
Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections.Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs.An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.
Highlights
Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections
Increased resistance to glycopeptides alongside with the search for a better tissue penetration and for protein synthesis inhibition has encouraged the development of new agents active against Gram-positive bacteria, for severe soft-tissue infections where aggressive antibiotic management is always recommended, such as linezolid and daptomycin
Primary wound closure is not recommended for wounds, with the exception of those to the face, which should be managed with copious irrigation, cautious debridement, and pre-emptive antibiotics
Summary
Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. One of the following oral antibiotics Amoxicillin-clavulanate 1 g every 8 h Cephalexin 500 mg every 6 h In patients at risk for CA-MRSA including immunocompromised status, personal or household contact with MRSA infection or colonization in the past 12 months, with prior antibiotic use for 5 days during the last 90 days, with cellulitis associated with penetrating trauma especially from illicit drug use or who do not respond to first-line therapy add one of the following oral antibiotics Trimethoprim and sulfamethoxazole 160/800– 320/1600 mg every 12 h Minocycline 100 mg every 12 h Doxycycline 100 mg every 12 h or Cephalexin 500 mg every 6 h or
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