Wound Repair and Experimental Wound Models

Abstract

Wound healing is the restoration of distorted cellular, biochemical and systemic processes with trauma to normalization with new tissue formation. Acute wounds are wounds in which the tissue can return to normal anatomical and functional integrity over a period of time, and treatment is relatively problem-free. Chronic wounds, on the other hand, are wounds in which anatomic and functional integrity cannot be achieved as a result of disruption of wound healing processes due to an underlying disease. Chronic wounds are a major health problem that affects a significant proportion of the population and reduces the quality of life. Moreover, wound care creates a significant financial burden on health systems in developed countries. With the technological advances in recent years, significant progress has been made in terms of drugs and medical devices used in wound treatment, however, despite these developments, experimental research in the field of wound therapy remains important due to the complex structure in wound healing processes and patient diversity. In this review, basic concepts and current applications used in wound research are discussed focusing on wound healing process and experimental wound models.