Abstract
BackgroundLonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicinal plant, is used to treat some infectious diseases and it may have uses as a healthy food and applications in cosmetics and as an ornamental groundcover. The ethanol extract of the flowering aerial parts of L. japonica (LJEE) was investigated for its healing efficiency in a rat excision wound model.MethodsExcision wounds were inflicted upon three groups of eight rats each. Healing was assessed by the rate of wound contraction in skin wound sites in rats treated with simple ointment base, 10% (w/w) LJEE ointment, or the reference standard drug, 0.2% (w/w) nitrofurazone ointment. The effects of LJEE on the contents of hydroxyproline and hexosamine during healing were estimated. The antimicrobial activity of LJEE against microorganisms was also assessed. The in vivo anti-inflammatory activity of LJEE was investigated to understand the mechanism of wound healing.ResultsLJEE exhibited significant antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans, and Candida tropicalis. The ointment formulation prepared with 10% (w/w) LJEE exhibited potent wound healing capacity as evidenced by the wound contraction in the excision wound model. The contents of hydroxyproline and hexosamine also correlated with the observed healing pattern. These findings were supported by the histopathological characteristics of healed wound sections, as greater tissue regeneration, more fibroblasts, and angiogenesis were observed in the 10% (w/w) LJEE ointment-treated group. The results also indicated that LJEE possesses potent anti-inflammatory activity, as it enhanced the production of anti-inflammatory cytokines that suppress proinflammatory cytokine production.ConclusionsThe results suggest that the antimicrobial and anti-inflammatory activities of LJEE act synergistically to accelerate wound repair.
Highlights
Lonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicinal plant, is used to treat some infectious diseases and it may have uses as a healthy food and applications in cosmetics and as an ornamental groundcover
It is used as a food, cosmetic and ornamental groundcover, and it can be consumed as a healthy beverage [6]
Biochemical analysis revealed increased hydroxyproline content, which is a reflection of increased cellular proliferation and increased collagen synthesis, after L. japonica ethanol extract (LJEE) ointment treatment [16]
Summary
Lonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicinal plant, is used to treat some infectious diseases and it may have uses as a healthy food and applications in cosmetics and as an ornamental groundcover. (Caprifoliaceae), a widely used traditional Chinese medicinal plant, is used to treat some infectious diseases and it may have uses as a healthy food and applications in cosmetics and as an ornamental groundcover. L. japonica is traditionally used as a medicinal plant [5] It is used as a food, cosmetic and ornamental groundcover, and it can be consumed as a healthy beverage [6]. The ethnopharmacological studies and clinical findings have demonstrated that L. japonica possesses many biological functions, including hepatoprotective, cytoprotective, antimicrobial, antioxidative, antiviral, and anti-inflammatory properties [6]. The major parts of this plant have medicinal properties: the flower buds have anticancer and anti-inflammatory properties [7], the leaves have antioxidant and tyrosinase-inhibitory properties [8], and the stem has tyrosinase-inhibitory, xanthine oxidase-inhibitory, and nitrite-scavenging activities [9]
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