Scientific validation of wound healing potential of Jasminum sambac Ait.

Abstract

Wounds are highly prone to various infections. The treatment of infected wounds is a big challenge. This paper presents an experimental analysis to evaluate its antimicrobial and antioxidant efficacies and the traditional claim of wound healing properties of Jasminum sambac. Excision and incision wound models were used to evaluate the wound healing activity on albino rats. The wound healing potential was assessed by measuring rate of wound contraction, the epithelialization period, hydroxyproline content, skin breaking strength and histopathology parameters. The standard drug used was nitrofurazone ointment. Antimicrobial activity was determined using diffusion and minimum (serial dilution) methods. The result showed that ethanolic extract of J. sambac leaves; exhibited a higher rate of wound contraction (84.15 ± 0.54% on 15th day), decrease in the period of epithelialization (17.83 ± 1.66 days), higher skin breaking strength (179.8 ± 1.79 g), higher collagen content and favorable histopathological changes compared to control group in both the models studied. The ethanolic extract was found to be most effective against Pseudomonas auregenosa having inhibition of zone 14.67 ± 0.9 mm and a minimum inhibitory concentration was 0.78 mg/ml. These results are significant in understanding the medicinal potential of Jasminum sambac.