Abstract
The regenerative activity of the protein kinase A inhibitor was investigated using externally on the model of the flap skin wound. The pronounced wound healing effects of the protein kinase A inhibitor had been revealed. They are based on the activation of mesenchymal progenitor cells. The development of this phenomenon was associated with the direct influence of the protein kinase A inhibitor on mesenchymal progenitor cells. The most significant stimulation of their growth potential occurred in the context of the impact of growth factors in particular fibroblast growth factor secreted by the stromal cells. Moreover, in situ, there was an increase not only in proliferating activity but also in the intensity of the specialization processes of progenitors. Without cytokines stimulation, the change in the pattern of cellular cAMP-mediated signal does not affect the maturation rate of precursors.
Highlights
There is a wide arsenal of wound healing drugs with different mechanisms of action
Production of growth factors by stromal cells from the surface of the wound Using cultural methods we studied the production of growth factors that stimulate the growth of CFU-F by stromal cells scraped from the surface of the wound
The results indicate the presence of pronounced wound healing properties in the cyclic AMP-dependent protein kinase A inhibitor in its external application
Summary
Some of them are a substrate for the formation of certain cell structures: nucleic acids and nucleotides (Liu et al, 2019), amino acids (Khalin et al, 2013), essential fatty acids (Silva et al, 2018), etc. These pharmacological substances stimulate cell proliferation in the damage zone by accelerating the synthesis of purine and pyrimidine bases, proteins, and other structural components of the cell. The development of highly effective wound healing drugs with fundamentally new mechanisms is relevant
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