Wound Healing Efficacy of Dexpanthenol Versus Beta-Sitosterol: A Comparative Study in a Rat Model

Abstract

Numerous types of cells and biological pathways must work together to repair damaged tissue for wounds to heal. Traditional treatments often fail to heal acute wounds, which can lead to gangrene, chronic wounds, or even amputation. The healing process is complicated and depends on a lot of different factors working together. This is what made people look for new treatments that are safe and work. MEBO and dexpanthenol have both been shown to play a role in the wound healing process by affecting different phases, such as inflammation, collagen deposition, angiogenesis, and re-epithelialization. Aim: Compare the Effect of Dexpanthenol and Beta-sitosterol (MEBO) In Wound Healing In Rats Methodology. Fifteen albino rats took part in this study and were split into three groups. (N=5/group). A punch biopsy was used to obtain a full-thickness 1-cm wound on the back of each rat. Group 1 Control: (animals without any treatment.) Group 2 β-sitosterol group: (animals were treated with β-sitosterol only, every 12 hr. for 10 days) Group 3 Dexpanthenol group: (animals were treated with Dexpanthenol only, every 12 hr. for 10 days) Results. All treated groups compared to the induced wound control group, caused a very significant decrease in wound size. (P≤0.001). Conclusion. 1-The topical application of MEBO cream accelerates wound healing through decreases in wound size, and promotion of angiogenesis, collagen deposition, re-epithelization, and modulation of inflammation. 2-The topical application of MEBO cream when used once a day for 10 days on an induced wound, seems to help the wound heal faster than Dexpanthenol so the use of beta-sitosterol is better than dexpanthenol in the treatment of wounds.