Abstract
The vast field of nanotechnology is significantly impacting both the global economy and human lives. Recently, metal nanoparticles have garnered attention as a potentially effective wound healing treatment, and the utilization of plant extracts for the biogenic synthesis of metal nanoparticles is a cost-effective and environmentally sustainable approach. The lack of scientific data to back up the claims made in ancient literature with binnendijkii species prompted the goals of this study. This motivates us to present a green method for synthesizing silver nanoparticles (AgNPs) utilizing hydroethanolic leaf extract from Ficus binnendijkii (FE) at different pHs and durations. The as-synthesized AgNPs and FE were applied separately to cotton fabrics, with or without 1% citric acid (CA) (as a bio-binder), under both normal and washing conditions to produce dressings that enhance wound healing. Quantitative analyses were performed to assess the total amounts of phenolic compounds, flavonoids, tannins, and alkaloids found in the FE, as well as HPLC to identify and quantify the phenolic compounds. All these phytochemicals play key roles in the assembly of AgNPs and wound healing. The biosynthesized nanoparticles were characterized using UV-vis spectroscopy, Fourier transform spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction patterns (XRD). Male albino rats were used in in vivo studies to investigate whether the AgNPs-containing dressing improved wound healing. The experimental results demonstrated the following findings: (i) The AgNPs exhibited a spherical shape, with sizes ranging from 3 to 15 nm and an average diameter of 6.40±2.87 nm. (ii) The most favorable conditions for the synthesis of AgNPs were determined to be a pH of 11 and an incubation time of 30 minutes. (iii) Cotton dressings loaded with a formulation containing AgNPs and 1% binder exhibited remarkable wound healing activity. Consequently, the utilization of this approach proves advantageous in terms of promoting effective wound healing.
Published Version
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