Abstract
Objective: Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed. Chronic wounds could be invaded by many bacteria and Pseudomonas aeruginosa and Staphylococcus aureus are the most common. S. aureus and P. aeruginosa are usually detected in the higher layer of wounds or in the deepest region of wound bed, respectively. They can express many virulence factors affecting wound healing process and leading to severe infections and antibiotic resistance. Methods: Starch based impregnated gauze containing either N. sativa honey, myrtle berries hydro-alcoholic extract or a combination were prepared. There efficacy against both P. aeruginosa and S. aureus isolated from chronic wounds. Results: N. sativa honey mixture was the most potent against P. aeruginosa with an inhibition zone diameter of 18.1±0.3 mm, while the myrtle berries hydro-alcoholic extract mixture was the most potent against S. aureus with an inhibition zone diameter of 18.4±0.5 mm. The prepared impregnated gauzes deliver a moist environment that helps wounds epithelialize more rapidly. Conclusion: In conclusion, honey and myrtle berries hydro-alcoholic extract provide antibacterial and anti-inflammatory properties that will accelerate the healing process of wounds. Peer Review History: Received 14 April 2018; Revised 25 April; Accepted 8 May, Available online 15 May 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Prof. Dr. Husniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY
Highlights
Bacterial resistance is less likely to develop as a result of treatment with honey because of the composition of honey which contains a number of different components responsible for the antimicrobial efficacy[15]
N. sativa honey was used in this study as it was found to be more potent on P. aeruginosa and S. aureus than other types of honey[23,24]
Impregnated gauze preparation Standard sterile gauze 3 inch by 3 inch was dipped into different starch based mixtures till saturation and the excess solution was extruded by applying pressure
Summary
A wound is defined as a simple or severe break in an anatomical structure such as the skin and can outspread to other tissues[1]. Bacterial resistance is less likely to develop as a result of treatment with honey because of the composition of honey which contains a number of different components responsible for the antimicrobial efficacy[15]. This includes pH, sugar content, hydrogen peroxide levels and the presence of some phytochemicals, mainly phenolic compounds including phenolic acids and flavonoids[16]. Many researchers report that honey could be an effective dressing for the treatment of different skin infections resulting from burns and wounds[19,20]. The anti-bacterial effect of impregnated sterile gauzes containing myrtle berries extract and Nigella sativa honey was studied on both P. aeruginosa and S. aureus
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