Abstract
Snakehead fish (Ophiocephalus striatus) (SF) is a type of fish that lives in fresh water and is widely known by the public. The properties and uses of SF have been scientifically proven to increase albumin levels and immune system as well as speed up the process of post-operative wound healing. The nutritional content of SF consists of albumin protein, amino acids, unsaturated fatty acids and minerals. Bioactive compounds that play a role in accelerating the wound healing process are albumin, glycine, and zinc (Zn). Wound healing is very dependent on the biochemical processes that occur on the skin involving intrinsic and extrinsic factors. This healing process will be accelerated with the help of dried SF extract which is designed in topical form such as cream or gel. Among albumin, glycine and Zn are important for wound healing because this protein is able to bind Zn and carry it in blood plasma. Zn deficiency reduces the wound healing process. Because of this nutrient, and other vitamins, it is present in SF extract so that it can trigger the formation of Endothelial Progenitor Cells (EPC) and accelerate wound healing. The presence of Zn in SF extract is likely to be a key factor playing a role in wound healing and also increases the appetite of children. Zn is an important mineral in the structure and function of cell membranes. Zn supplementation can limit membrane damage which is caused by free radicals during inflammation. Furthermore, Zn is also involved in the immune system, from the defense system by the skin to the regulation of genes in lymphocytes.
 Peer Review History: 
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 Received file 
 
 Average Peer review marks at initial stage: 6.0/10
 Average Peer review marks at publication stage: 7.5/10
 Reviewer(s) detail:
 Name: Asmaa Ahmed Mohamed Ahmed Khalifa 
 Affiliation: Pharos University, Alexandria, Egypt
 E-mail: asmaa.khalifa@pua.edu.eg
 
 Name: Dr. Marwa A. A. Fayed 
 Affiliation: University of Sadat City, Egypt
 E-mail: maafayed@gmail.com
 Comments of reviewer(s): 
Highlights
Snakehead fish (Ophiocephalus striatus) (SF) is a type of fish that lives in fresh water and is widely known by the public
The potential of snakehead fish in accelerating the wound healing process greatly helps improve the degree of public health
This is related to the nutritional content of snakehead fish such as albumin, glycine and Zn
Summary
Indonesia is an archipelago that is rich in natural materials from marine plants and marine animals. The efficacy and use of SF has been scientifically proven to increase albumin levels and endurance as well as speed up the process of postoperative wound healing[2]. Taslim’s research results (2005) showed that the administration of SF water extract as much as 100 ml every day for 3 days increased levels of albumin and total protein of patients. (2006) showed that administration of albumin for wound healing in the form of SF capsules daily for 5 days on hypo-albumin of post-operative patients at Wahidin Sudirohusodo Hospital, Makassar had been able to increase albumin levels by an average of 0.74 g/dl/day followed by improvement in nutritional status compared to the control group[6].
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