Year-end Sale % OFF 
Abstract
This chapter explains the complexity of excision repair mechanisms in bacteria that underscores the need for further experimentation. The excision repair scheme involving incision, excision, resynthesis, and ligation is almost certainly well founded and considerable progress has been made toward understanding the details of individual steps. The excision of the cross-link appears to require the 5’→3’exonuclease of DNA polymerase I as well as the uvr D gene product. The chapter also discusses the difficulties caused by postirradiation DNA degradation and experiments involving high levels of DNA degradation, which should be interpreted cautiously. As of yet, the incision step at the site of pyrimidine dimers is not completely understood. As the nature and location of the incision probably determines the type of substrate available to excision and resynthesis enzymes, the incision event itself may dictate as to which of the available excision repair pathways is followed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
