Abstract
ABSTRACT Base-excision repair of DNA damaged by chemicals relies upon the sequential action of specific DNA-glycosylases wich excises the modified bases yielding an apurinic or apyrimidinic site. This site is in turn recognised by a specific endonuclease wich hydrolyse the phosphodiester bond of DNA adjacent to this site. In M.luteus an uracil-DNA-glycosylase split off uracil in a DNA containing such a base. An independant 3-methyladenine DNA-glycosylase liberates 3-methyladenine from alkylated DNA but not 7-methylguanine. The apurinic or apyrimidinic sites are recognized by one of the two endonucleases specific for such sites and hydrolyse the phosphodiester bond of DNA.
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