Abstract
Benzimidazoles have potential for developing important drugs and fighting cancerous gastric cells. In this study, an efficient and eco-friendly photocatalyst, WO3-ZnO, is used to synthesize some 2-substituted benzimidazoles by condensing aromatic aldehydes with o-phenylenediamine. The synthesis is achieved by irradiation with a commercial green laser. Various techniques like FT-IR, XRD, DLS, UV–Vis, and FE-SEM are used to analyze structure and properties of WO3-ZnO. The nanocatalyst shows excellent reusability and reproducibility. Additionally, cytotoxicity of WO3-ZnO nanoparticles are tested against KATO-III human gastric cancer cells, and MTT assay confirms their cytotoxicity with a significant reduction in cell viability. The cytotoxicity of WO3-ZnO nanoparticles against the performed cell line under in vivo conditions will be directed soon and the obtained results will be compared with the in vitro conditions.
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