WITHDRAWN: Prevalence of Non-Proteinuric Preeclampsia at Mansoura University Hospitals

Abstract

ObjectivesPre-eclampsia (PE) is a complex, multisystem disorder of unknown aetiology. PE is the development of hypertension and proteinuria in a previously normotensive woman at or after 20 weeks of gestation. Recently, the definition has been broadened to include non-proteinuric, in addition to proteinuric PE, accompanied by evidence of maternal organ dysfunction and uteroplacental dysfunction. MethodsThis cross-sectional study included pregnant women at 20 weeks gestation or more who attended an outpatient clinic and were admitted to the Obstetrics and Gynecology Department over 12 months (from July 2020 to June 2021) due to hypertension with or without proteinuria. A blood sample was taken to investigate the haemoglobin, platelet, liver, and renal function. Doppler study of the umbilical and middle cerebral artery were done to assess the uteroplacental function. ResultsOf two types of PE among the total of 889 cases, prevalence of proteinuric PE (110/889 or 12.3%) was significantly higher than non-proteinuric PE (55/889 or 6.1%) (OR and 95% CI = 2.1 (1.5–3.0) P < 0.0001). ConclusionThe prevalence of non-proteinuric PE (6.1%) is about half of proteinuric (12.3%), which has broadened the scope of diagnosis of PE to be non-proteinuric and proteinuric instead of just proteinuric. Liver involvement was significantly more frequent in proteinuric PE, while uteroplacental dysfunction was more frequent in non-proteinuric PE.