Abstract
Abstract Platelet-rich fibrin (PRF) plays an increasingly active role in the repair of soft tissue defects in oral implants, but it still requires a long observation period, systematic description of PRF to repair oral soft tissue defects in animal experiments to consolidate the relevant theoretical basis. New Zealand rabbits were selected as experimental subjects. The experimental rabbits were randomly divided into three groups: PRF group, collagen membrane group and blank control group. Each experimental rabbit was in the middle part of the hard palate, which was separated from the maxillary posterior incisors and left and right hard palate. A circular soft tissue full-thickness defect area was prepared by a tissue ring-cutting drill with a diameter of 5 mm at 2 mm of the mucosal edge. Three groups were implanted with PRF membrane and collagen biofilm, and the blank control group was not treated. The healing morphology, wound healing rate, inflammatory response, collagen formation and angiogenesis were observed. The healing effect of soft tissue defects in PRF oral implants was studied.
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