WITHDRAWN: Green synthesis of Ag nanoparticles using Mentha arvensis extract: Preparation, characterization and investigation of its anti-human bladder cancer application

Abstract

• Silver nanoparticles green-synthesized by Mentha arvensis extract as reducing/stabilizing agent. • The IC 50 of AgNPs was 59 µg/ml in the antioxidant test. • The IC 50 of the AgNPs were 250, 298, 176, and 129 µg/mL against HT-1376, TCCSUP, SCaBER, and UM-UC-3 cell lines, respectively. In this study, silver nanoparticles green-synthesized by Mentha arvensis extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared silver nanoparticles were determined using several advanced techniques. Hence, our protocol is green and advantageous in terms of- i) biochemical modified biocompatible nanoparticles; ii) nanomaterial providing high surface area and larger number reactive sites; iii) very simplistic synthetic procedure; iv) very low load of metal in the composite and v) high yield in short time. In the medicinal part, the anticancer properties of silver nanoparticles against bladder cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC 50 of silver nanoparticles was 59 µg/ml in the antioxidant test. The IC 50 of the silver nanoparticles were 250, 298, 176, and 129 µg/mL against bladder cancer (HT-1376, TCCSUP, SCaBER, and UM-UC-3) cell lines, respectively. In addition, the current study offer that silver nanoparticles could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.