WITHDRAWN: Formulation and evaluation of Ferulic acid and Oleic acid containing liposomal gel for skin nourishment

Abstract

AimThis study aimed to develop a topical drug delivery system using a liposomal gel loaded with Ferulic acid and Oleic acid, with a dual focus on the treatment of aging skin and skin nourishment. ObjectivesTo formulate liposomes containing Ferulic acid and Oleic acid via the thin-film hydration technique. To incorporate the optimized liposomes into a Carbopol® 934 gel matrix. To comprehensively characterize the physicochemical properties of the liposomes and liposomal gel. To evaluate the potential of the developed liposomal gel as an efficacious topical solution for addressing skin aging and promoting skin nourishment. MethodsLiposomes were meticulously prepared using the thin-film hydration technique and were subsequently integrated into a Carbopol® 934 gel matrix. A range of crucial assessments were conducted, encompassing entrapment efficiency, drug loading, particle size, polydispersity index (PDI), and zeta potential. The physicochemical attributes of both the liposomes and liposomal gel were systematically examined. The study also sought to evaluate the potential of the liposomal gel for its dual role in combating skin aging and enhancing skin nourishment. ResultsThe optimized liposomes exhibited remarkable characteristics, including an entrapment efficiency of 95.1%, drug loading of 67.5%, a particle size of 1028 ​nm, a polydispersity index (PDI) of 0.488, and a zeta potential of -49 mV. These parameters underscored the successful formulation of Ferulic acid and Oleic acid-loaded liposomes, which were seamlessly incorporated into the Carbopol® 934 gel matrix. ConclusionIn conclusion, the Ferulic acid and Oleic acid-loaded liposomal gel developed in this study holds significant promise as a topical drug delivery system for both the treatment of aging skin and skin nourishment. The high entrapment efficiency, substantial drug loading, and desirable particle size and zeta potential collectively demonstrate the efficacy of this liposomal gel as a versatile delivery platform. It has the potential to effectively address clinical manifestations of aging skin, including wrinkles, loss of elasticity, and textural irregularities, while simultaneously providing essential nourishment to the skin. Further in vivo investigations are warranted to ascertain the therapeutic effectiveness and safety of this liposomal gel in the context of skin aging treatment and nourishment.