Abstract
Background and aimThe therapeutic effects of pioglitazone (Pio), dexamethasone (Dexa) and Curcuma longa (Cl) on inhaled paraquat (PQ)-induced lung oxidative stress, inflammation, pathology changes and tracheal responsiveness were evaluated. Experimental procedureOne group of rats was exposed to saline (group C) and six groups to PQ aerosols. One group of PQ-exposed rats was given drinking water alone (group PQ), while other groups were received drinking water containing; two doses of Cl. (150 and 600 mg/kg, Cl-L and Cl–H), Pio (5 mg/kg), Pio + Cl-L and Daxa (0.03 mg/kg), (7 rat in each group). Results and conclusionIn PQ group, total and differential WBC counts, malondialdehyde (MDA) in the BALF, cytokine levels (INF-γ and IL-10), lung pathological changes and TR were remarkably increased but the BALF thiol, catalase (CAT) and superoxide dismutase (SOD) levels were reduced (for interstitial necrosis, p < 0.05 and for other cases, p < 0.001). Treatment of rats with Cl–H and Pio + Cl-L, significantly improved all measured variables, treatment with Pio and Cl-L improved most variables and treatment with Pio only few variables (p < 0.05 to p < 0.01). The improvements in almost all variables (except some pathological changes) in the Pio + Cl-L group were significantly higher than the Pio and Cl-L groups alone (p < 0.05 to p < 0.001).Curcuma longa ameliorated lung damage induced by inhaled PQ similar to dexamethasone and Pio and a synergic effect between Cl and Pio was observed, suggesting, amplified the activation effects of Pio on PPARs by Cl.
Published Version
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