Abstract
Ras Puts the Brake on Doxorubicin-mediated Cell Death in p53-expressing Cells Journal of Biological ChemistryVol. 286Issue 9PreviewDoxorubicin is one of the most effective molecules used in the treatment of various tumors. Contradictory reports often open windows to understand the role of p53 tumor suppressor in doxorubicin-mediated cell death. In this report, we provide evidences that doxorubicin induced more cell death in p53-negative tumor cells. Several cells, having p53 basal expression, showed increase in p53 DNA binding upon doxorubicin treatment. Doxorubicin induced cell death in p53-positive cells through expression of p53-dependent genes and activation of caspases and caspase-mediated cleavage of cellular proteins. Full-Text PDF Open Access VOLUME 286 (2011) PAGES 7339–7347 This article has been withdrawn by the authors.
Highlights
Withdrawal: Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells
This article has been withdrawn by the authors
Authors are urged to introduce these corrections into any reprints they distribute
Summary
Withdrawal: Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells.
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