Abstract
Wilms Tumor (WT) is an extremely rare neoplasia in adults. It represents 95% and 1% of all renal tumors, in adults and children respectively. Clinical symptoms are also distinct between adults and children. In adults, symptoms are usually abdominal pain and hematuria, on the other hand, pediatric patients frequently present with an asymptomatic abdominal mass. The recommended treatment for WT in adults follows protocols established for pediatric patients. Currently, the 5-year overall survival rate for adults with WT is of approximately 90%. The adoption of multimodal therapy systematized, and proposed by current protocols, allowed the results to become much more robust, with a significant improvement from less than 30% to 90%. However, recent reviews suggest a worse outcome for adults when compared to children, even when submitted to the same treatment regimen, and comparable according to histology and tumor stage.We present a case of a 26 years-old male patient, who underwent surgery to treat a solid renal mass. Pathological report demonstrated a Wilms tumor. The patiente also received adjuvant chemotherapy with dactinomycin and vincristine. After 12 months follow-up, patient has no evidence of disease.
Highlights
Wilms tumor (WT), known as nephroblastoma, is an extremely rare tumor with few reports in the literature
WT is an embryogenic tumor, originated from nephrogenic blastemal cells, which replicates the histology of the kidneys and usually exhibits various patterns of differentiation
WT is an extremely rare neoplasia in adults. While in children it represents about 95% of renal neoplasms, 4 in adults it corresponds to less than 1% of all kidney cancers[5]
Summary
Wilms tumor (WT), known as nephroblastoma, is an extremely rare tumor with few reports in the literature. Cancer control rates of WT are worse in adults when compared to children The reason for this disparity are factors such as diagnosis in advanced stages, lack of the knowledge of the pathology by oncologists and pathologists, absence of standardized treatment protocols and delay of risk stratification to define adjuvant treatment[3]. Patient is 26-year-old male who initially presented with macroscopic hematuria associated with left flank pain He had a feeling of abdominal mass on the left flank. Patient felt pain and showed a 12 cm palpable hard mass in the upper left quadrant. He referred a family history of a daughter operated when she was 2 years old by adrenal tumor there was no pathology report available. After 12 months follow-up, patient is still free of disease
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