Abstract
Background During the intra-erythrocytic stage, Plasmodium parasites degrade hemoglobin resulting in ferriprotoporphyrin (IX) accumulation; toxic to the parasite [1]. bHematin, a synthetic polymer made from ferriprotoporphyrinIX is structurally, chemically and spectroscopically identical to purified hemozoin is used in in-vitro studies [1]. Resistance to Chloroquine, highlights the need for new drugs. Earlier attempts showed the effect of pyrimidine derivatives in in-vitro inhibition of b-hematin [2], and cisplatin complexes [3]. We concentrate on finding new molecules from natural products; (Salvia officinalis).
Highlights
During the intra-erythrocytic stage, Plasmodium parasites degrade hemoglobin resulting in ferriprotoporphyrin (IX) accumulation; toxic to the parasite [1].b- Hematin, a synthetic polymer made from ferriprotoporphyrin- IX is structurally, chemically and spectroscopically identical to purified hemozoin is used in in-vitro studies [1].Resistance to Chloroquine, highlights the need for new drugs
Extracts were filtered using MN615- F 90 nm filter paper, rotary evaporated at 50°C lyophilized to constant weight
The final precipitate of b-hematin dissolved in 200μl of 0.1 M NaOH to give alkaline hematin for spectroscopic quantification at 405 nm
Summary
During the intra-erythrocytic stage, Plasmodium parasites degrade hemoglobin resulting in ferriprotoporphyrin (IX) accumulation; toxic to the parasite [1]. B- Hematin, a synthetic polymer made from ferriprotoporphyrin- IX is structurally, chemically and spectroscopically identical to purified hemozoin is used in in-vitro studies [1]. Resistance to Chloroquine, highlights the need for new drugs. Earlier attempts showed the effect of pyrimidine derivatives in in-vitro inhibition of b-hematin [2], and cisplatin complexes [3]. We concentrate on finding new molecules from natural products; (Salvia officinalis)
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