Abstract
With the widespread use of high-efficiency antiretroviral therapy (HAART), the life expectancy of HIV-infected patients has been significantly extended. However, the metabolic complications among HIV-infected patients treated with HAART have become the most common problem in the world. It is very important to explore the incidence of dyslipidaemia and studies on the role of potential risk factors in HIV-infected Chinese patients treated with HAART are sparse. Therefore, we designed current study, to investigate the effects of therapeutic intervention and continuous information support on the lifestyle of HIV/AIDS patients with dyslipidaemia. Three hundred and six HIV/AIDS patients admitted to the AIDS clinic in Beijing from January 2016 to January 2017 were recruited and assigned into two groups: the treatment group (n=64) and the control group (n=64). The median age of the participants was 38.8±11.0 years (range 20-75 years). The prevalence of dyslipidemia in control and treatment group was (59/64) 92.2% and (53/64) 82.8%, respectively. In this study, low HDL-cholesterol (HDLC) led to abnormalities 47/64 (73.3%) in the control group and 35/64 (54.7%) in HAART-treatment group. Additionally, HAART group showed higher triglyceride, total cholesterol, and low-density lipoprotein (246.1±171.8, 1.73±1.61 mmol/L, 4.46±1.1 mmol/L, 2.54±0.74 mmol/L). In multivariate analysis, gender, marital status, high BMI, dietary habits and physical activity were potential risk factors for dyslipidemia in HIV-infected Chinese patients. In this study, we reported high prevalence dyslipidemiain two HIV infected groups. We suggest that the appropriate diagnosis should be performed for analyzing the metabolic complications in HIV-infected Chinese patients. Further studies are very important to understand the role of potential risk factors in metabolic complications.
Highlights
AIDS is an infectious disease characterized by immunodeficiency caused by human immunodeficiency virus (HIV) (Brooks, Buchacz, Gebo, Mermin, 2012)
We assessed the prevalence of metabolic complications in HIV-infected Chinese patients, and further we explored the possible role of potential risk factors for the occurrence of metabolic complications in HIV-infected Chinese patients
In many studies that have already been reported, HIV disease is linked with decreased concentrations of Total cholesterol (TC), LDLC, and HDLC, whereas hypertriglyceridaemia has a positive correlation with lipid abnormalities and the degree of immune-suppression
Summary
AIDS is an infectious disease characterized by immunodeficiency caused by human immunodeficiency virus (HIV) (Brooks, Buchacz, Gebo, Mermin, 2012). The HIV/AIDS epidemic continues to pose a humanitarian crisis to the world’s most disadvantaged communities. 36.9 million people are infected with HIV, 70% of who reside in sub-Saharan Africa. Antiretroviral therapy (ART) confers those adherents to the lifelong drug regimen near normal life expectancy. According to statistics from China CDC, as of 2015, there were about 580,000 HIV/AIDS patients in China. The main treatment for AIDS is high-efficiency antiretroviral therapy (HAART). HAART treatment can significantly inhibit HIV replication and reduce viral invasion, greatly prolonging the lifespan of HIV/ AIDS patients (Grinsztejn et al, 2013;Lynch, Clark, Zhanel, (2013). Long-term HAART treatment brings a series of metabolic abnormalities to HIV/ AIDS patients. Hyperlipidemia is one of the most common manifestations, as well as one of the important
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