Abstract
The emerging NDM-producing Enterobactereciae is a major threat to public health. The association of NDM-7 with sequence type 101 E.coli is identified in very few numbers. Therefore, it is of interest to analyse the whole genome sequence of NDM-producing uropathogenic E. coli XA31 that was found to carry numerous drug resistance genes of different antibiotic classes. The isolate E. coli belongs to ST-101 carrying blaNDM-7 coexisting with several resistance genes blaOXA-1, blaTEM1-A, blaCTX-M15, aac(6')-Ib-cr, catB3, tetB. Resfinder predicts this and four other plasmid replicons were identified using the Plasfinder in the CGE platform. The high transferable IncX3 plasmid was found to carry the NDM-7 gene. Thus, we the report the combination of NDM-7-ST101-IncX3 in India. The combination of this epidemic clone with NDM-7 is highly required to develop an effective infection control strategy.
Highlights
The majority of community-acquired and nosocomial spread of Urinary tract infection (UTI) is highly mediated by the uropathogenic Escherichia coli (UPEC) in humans
It is of interest to analyse the whole genome sequence of New Delhi Metallo β lactamase (NDM)-producing uropathogenic E. coli XA31 that was found to carry numerous drug resistance genes of different antibiotic classes
Though the Escherichia coli is the major determinant of urinary tract infection it involve in causing other diseases including bacteraemia and liver abscesses [2]
Summary
The majority of community-acquired and nosocomial spread of Urinary tract infection (UTI) is highly mediated by the uropathogenic Escherichia coli (UPEC) in humans. Though the Escherichia coli is the major determinant of urinary tract infection it involve in causing other diseases including bacteraemia and liver abscesses [2] These bacterial strains develop resistance to β-lactam antibiotics through conferring ESBL [3]. A new paradigm was developed through preclinical treatment as a new compound ANT 2681 combine with meropenam to overcome serious infection of NDM producing Enterobacteriaceae [7] Of these NDM variants, the majority of them have successfully disseminating on most of the Enterobacteriaceae by mobilizing into various plasmid incompatible groups like IncX3, IncA/C2, and IncF, IncH, and IncL/M [6], through different molecular evolutionary events like horizontal gene transfer and others [8]. It is of interest to analyse the whole genome sequence of NDM-producing uropathogenic E. coli XA31 that was found to carry numerous drug resistance genes of different antibiotic classes
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