Whole-Exome Sequencing Identifies Mutation Profile and Mutation Signature-Based Clustering Associated with Prognosis in Appendiceal Pseudomyxoma Peritonei.

Yu-Lin Lin,Jun-Qi Zhu,Ru Ma,He-Liang Wu,Wei Meng,Rui-Qing Ma,Xin-Bao Li,Ying Gao,Zi-Yue Wang,Hong-Bin Xu,Yan Li

doi:10.1158/1541-7786.mcr-22-0801

Whole-Exome Sequencing Identifies Mutation Profile and Mutation Signature-Based Clustering Associated with Prognosis in Appendiceal Pseudomyxoma Peritonei.

Yu-Lin Lin, Jun-Qi Zhu + Show 9 more

https://doi.org/10.1158/1541-7786.mcr-22-0801

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Journal: Molecular cancer research : MCR	Publication Date: Sep 28, 2023
Citations: 2

Affiliation: Beijing Shijitan Hospital, Aerospace Center Hospital, Tsinghua University

#Appendiceal Pseudomyxoma Peritonei #High-grade Mucinous Carcinoma Peritonei #Tumor Mutation Burden #Mutation Profile #Pseudomyxoma Peritonei #Mutation Signatures #Focal Adhesion Pathways #cAMP Signaling Pathway #Whole-exome Sequencing Data #Microsatellite Instability

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This work describes exhaustive mutation profile of PMP based on WES data and derives ten mutation signatures, which divides patients into two clusters and serve as an independent prognostic factor associated with 3-year survival.

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Whole-Exome Sequencing Identifies Mutation Profile and Mutation Signature-Based Clustering Associated with Prognosis in Appendiceal Pseudomyxoma Peritonei.