Abstract
When fast skeletal muscles are activated, cytosolic [Ca2+]cyto increases while Parvalbumin (PV) acts as a buffer, releasing Mg2+ and binding Ca2+, playing a crucial role in muscle relaxation and plasticity. A recent work on PV knockout (KO) mice elucidated its role also in mitochondrial remodeling and fiber size regulation (Butera et al 2021). Strikingly, in FDB fibers of PV-KO mice, both the [Ca2+]cyto and the sarcoplasmic reticulum [Ca2+]SR levels are not different form the wild-type (WT) mice in basal conditions and during 60Hz stimulations.
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