White matter alteration in adults with prelingual deafness: A TBSS and SBM analysis of fractional anisotropy data

Abstract

A loss of hearing in early life leads to diversifications of important white matter networks. Previous studies related to WM alterations in adult deaf individuals mainly involved univariate analysis of fractional anisotropy (FA) data and volumetric analysis, which yielded inconsistent results. To address this issue, we investigated the FA value alterations in 38 prelingual adult deaf individuals and compared the results with those obtained from the same number of adults with normal hearing by using univariate (tract-based spatial statistics) and multivariate (source-based morphometry) methods. The findings from tract-based spatial statistics suggested an increased FA value in regions such as the left cingulate gyrus, left inferior frontal occipital fasciculus, left inferior longitudinal fasciculus and superior corona radiata; however, the results indicated a decreased FA value in the left planum temporale of adult deaf individuals. While source-based morphometry analysis outlined higher FA values in regions such as bilateral lingual gyrus, bilateral cerebellum, bilateral putamen and bilateral caudate, a considerable decrease was observed in the bilateral superior temporal region of the deaf group. These alterations in multiple neural regions might be linked to the compensatory cross-modal reorganizations attributed to early hearing loss.