Abstract

Optical resonators are sensors well known for their high sensitivity and fast response time. These sensors have a wide range of applications, including in the biomedical fields, and cancer detection is one such promising application. Sensor diagnosis currently has many limitations, such as being expensive, highly invasive, and time-consuming. New developments are welcomed to overcome these limitations. Optical resonators have high sensitivity, which enable medical testing to detect disease in the early stage. Herein, we describe the principle of whispering-gallery mode and ring optical resonators. We also add to the knowledge of cancer biomarker diagnosis, where we discuss the application of optical resonators for specific biomarkers. Lastly, we discuss advancements in optical resonators for detecting cancer in terms of their ability to detect small amounts of cancer biomarkers.

Highlights

  • Cancer, a hazardous non-communicable disease, is currently the main challenge in healthcare.Cancer Research UK shows that more than 14.1 million people had cancer in 2012 [1]

  • We briefly introduce cancer biomarkers discuss sensors, and describe whispering-gallery resonators (WGR) and ring resonators in more detail

  • We review recent works on the application of optical resonators in cancer biomarker detection focused on early stage detection

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Summary

Introduction

A hazardous non-communicable disease, is currently the main challenge in healthcare. It clear is clear at (a) initial stage of cancer development, patients have significantly larger chances of being cured. A. Apart from the emotional concern of scarring diagnosis is the result of difficulty in making worry regarding doctor availability,even and from unfortunate discovery, the findings reflectappointments, the difficulty in accessing diagnostic technologies unwillingness to learn ofCurrently, the development of canceris[8]. The centralized medical complex was time, and as the world population increased exponentially, more patients have become dependent on introduced the early 17th century enhancing theoverwhelming mobility of technology andhealthcare knowledge. Diagnostic treatment capability limited byrole the in capacity of the ideology available times andThe steps, modernand biosensors have come to are playthen an important fulfilling technology.

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Performance Parameters of Optical Resonators
Light Coupling
Whispering-Gallery Mode
Detection Mechanism
Diagram
Optical
Microring and Microtoroid Optical Resonators
Sensor Surface Functionalization
Sample Preparation
Cancer Biomarkers
Conclusions
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