Abstract
Concurrent chemoradiotherapy is the standard of care in the management of locally advanced NSCLC, with disappointing results in terms of local tumor control and overall survival. Hystorically, it has been demonstrated a strict dose–response relationship in thoracic radiotherapy for lung cancer and, therefore, dose escalation was tested in many prospective trials. In this paper, we briefly review the most relevant publications focusing on dose management in terms of dose escalation with both conventional and altered fractionation schedules.
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