Abstract
Aim: The tumor microenvironment of NSCLC with driver mutations, such as EGFR, ALK and ROS, is less inflammatory. Materials & methods: This retrospective study included 38 patients with NSCLC driver mutations. The relationship between clinical and inflammatory markers concerning progression-free survivaland overall survivalwas analyzed based on Kaplan-Meier curves. Results: The mean age of the patients was 59.8±11.9. Progression-free survivaland overall survivalwere significantly longer in patients under 65years of age and with low neutrophil-lymphocyte ratio, low systemic immune-inflammation index and high lymphocyte count (p<0.05). Conclusion: Unlike tumor biology, peripheral inflammatory parameters, such as neutrophil-lymphocyte ratio, systemic immune-inflammation indexand lymphocyte count may be associated with survival in NSCLC patients with driver mutations.
Published Version
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